Investigation of Poly(amidoamine) Dendrimer Based Simvastatin Oral Formulations: Pharmacokinetic and Pharmacodynamic Studies
نویسندگان
چکیده
Dendrimers have a highly branched nanoscale architecture with low polydispersity and high functionality. Therefore, dendrimers been widely used for nanocarriers in drug delivery systems. This paper gives an overview of the recent progress on the evaluation of pharmacokinetic and pharmacodynamic (PK/PD) profiles of PAMAM dendrimers based Simvastatin (SMV) oral formulation in rats. The mechanism of the dendrimer delivery of SMV will be also presented.
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